EIAgen Tissue Transglutaminase IgA

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Transglutaminase

brief description

Gluten-sensitive patients develop IgA and IgG antibodies to gliadin and to a component of the gut endomysium. Recently, tissue transglutaminase , a calcium-dependent enzyme that catalyzes the transamidation of specific polypeptide-bound glutamine residues, has been identified as the unknown endomysial antigen. Interestingly, gliadin is the preferred substrate for this enzyme creating antigenic neoepitopes which are thought to generate the immune response in genetically susceptible individuals. The immunological detection of IgA autoantibodies to tTGA is a useful tool in the diagnosis and follow-up of celiac disease. The presence of IgA autoantibodies to tTGA closely correlates with the detection of anti-endomysial antibodies.

intended use

The EIAgen Tissue Transglutaminase IgA kit is a rapid ELISA method for the detection of circulating IgA antibodies to tissue transglutaminase (t-Tg).