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Product Code. K90**

Intended use:

For in vitro diagnostic use. The RIDASCREEN® Candida tests are enzyme immunoassays for the semi-quantitative determination of IgA, IgG, or IgM antibodies against Candida albicans and antigenically related species in human serum. The tests should be used for confirmation purposes when there is a suspected case of infection with candida or for clarifying the immune status.

 General information:

Candida albicans is part of the human microflora. Excessive and unimpeded growth is generated by a disruption of the sensitive balance and manifests itself in form of oral and/or vaginal soor. Spread of Candida in body tissues causes a systemic candidiasis.
Even though there are more than 100 species of Candida, only 7 have been isolated with greater frequency from medical samples. In over 80% of the fungus isolates, Candida albicans and Candida tropicalis are found. Due to colonization of mucous membranes with Candida albicans and its passage into the host's blood stream, the humoral immune system is stimulated, which results in the production of antibodies against Candida albicans. Generally, shortly after the antigen infringement, Candida albicans-specific IgM-antibodies are produced which are followed by an increase in specific IgG antibodies. Excessive infection of mucous membranes can lead to a high titer of Candida albicans-specific IgA-antibodies.

Test principle
Purified antigens are coated to a microwell plate. Antibodies in the patient samples bind to the antigens and are determined during the second incubation step by using enzyme-labelled anti-human antibodies (the conjugate). The enzyme converts the colourless substrate (H2O2/TMB) to a blue end product. The enzyme reaction is stopped by adding sulphuric acid and the colour of the mixture switches from blue to yellow at the same time. The final measurement is carried out at 450 nm on a photometer using a reference wavelength ≥ 620 nm.


Format: Art. No. K9011
Candida IgA (96 tests)

Art. No. K9021
Candida IgG (96 tests)

Art. No. K9031
Candida IgM (96 tests)

The test kits contain a microtiter plate with 96 wells (12 strips with 8 wells each; strips can be divided into single wells).
Incubation time: 3 x 30 min at 37 ºC
Sensitivity: 100.0% (IgA)
87.5% (IgG)
87.8% (IgM)
Specificity: 98.2% (IgA)
100.0% (IgG)
100.0% (IgM)

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