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EIAgen Parvovirus B19 IgM



brief description

Parvoviruses are cubic single-stranded DNA viruses of about 18-32 nm lacking an envelope. Parvovirus B19 intects only humans, and since there are no cross-reactivities between animal parvoviruses and B19, transmission between pets and humans is not possible. Parvovirus B19 is the causative agent of Erythema infectiosum, the so-called "fifth disease", a mild rash illness that occurs most commonly in children. Infected persons are contagious during the early part of the illness before the rash appears so in adults the rate of epidemia ampunts to about 60%. Symptoms of fifth disease are "slapped-cheek" rash on the face and a lacy red rash on the trunk and limbs in kids. Adults may develop joint pain or swelling (hands, wrists and knees). The mechanism of infection is based on person-to-person transmission: virus is pread by direct contact with respiratory secretions (e.g., saliva, sputum or nasal mucus). About 20% of adults and chldren who are intected with Parvovirus B19 do not develop any symptoms. Persons infected with the virus, however, do develop lasting immunity that protects them again infection in the future. Parvovirus B19 infection may cause a serious illness in persons with sickle-cell disease or similar types of chronic anemia as well as in persons who have problems with their immune system (people with leukemia or cancer, who are born with immuno deficiences, who have received an organ transplant, or who have HIV infection). Occasionally (less than 5% of all pregnant women infected with parvovirus B19) serious complications may develop during pregnancy: risk of Morbus haemolyticus fetalis.

intended use

The EIAgen PARVOVIRUS B19 IgM kit is an Enzyme-immunoassay for the qualitative determination of IgM antibodies against Parvovirus B19 in human serum.

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