EIAgen Free T4

brief description

Thyroxine or 3, 5, 3', 5', -tetraiodo-L-thyronine (T4) is a thyroid hormone with a molecular weight of 777 synthesized in the thyroid gland by iodination of tyrosine bound to the specific protein thyroglobulin. As part of the thyroglobulin molecule, T4 is stored in the follicles of the thyroid gland. When T4 is needed, the thyroglobulin is hydrolyzed and T4 is released into the bloodstream. In serum, T4 exists in a reversible equilibrium be-tween two states, bound and free. T4 bound to serum binding proteins, primarily thyroxine binding globu-lin (TBG), and to a lesser degree thyroxine binding prealbumin (TBPA) and albumin, represents greater than 99 % of the total thyroxine.

intended use

EIAgen Free T4 is a direct solid phase enzyme immunoassay for the quantitative determination of free Thyroxine (fT4) in human serum