EIAgen FSH

brief description

Follicle-stimulating hormone (FSH, follitropin) is a 33 kDa glycoprotein hormone secreted by the anterior pituitary gland. The intact FSH molecule is noncovalently-linked dimer containing alpha and beta subunits. The FSH alpha subunit is homologous to the alpha subunits of several other glycoprotein hormones, including luteinizing hormone (LH), thyroid-stimulating hormone (TSH) and human chorionic gonadotropin (hCG). However, each hormone has a unique beta subunit. Both LH and FSH production and secretion are stimulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus. GnRH release is normally pulsatile, resulting in episodic release of both FSH and LH. FSH production and secretion are regulated by a complex balance of endocrine feedback systems involving a number of steroid (estrogen, testosterone and progesterone) and peptide (inhibins, activins, follistatin) hormones. FSH is cleared by both hepatic and renal mechanisms.

intended use

EIAgen FSH is a direct solid phase enzyme for the quantitative determination of Follicle-Stimulating Hormon (FSH) in human serum.