EIAgen Estradiol

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Steroids and Fertility

brief description

Estradiol (E2) is a steroid hormone with a molecular weight of 272.4 Dalton. It is composed of 18 carbon units and it is the most active estrogen hormone. The synthesis of E2 occurs mainly in the ovary, moreover small amounts of E2 are synthesized by adrenal cortex and by testis, or by periferal conversion of Testosterone. For these reasons also during the menopause, when ovary function is altered and as well in the man, circulating E2 is detectable, even if in small aliquots. The main biosynthetic pathway goes through D4-androstenedione and estrone which is converted in estradiol. In woman, during the normal menstrual cycle, the thecal cells of the developing and ripe Graafian follicle secrete estradiol into follicular antrum and into ovarian vein.

intended use

EIAgen Estradiol is a direct solid phase enzyme immunoassay for the quantitative measurement of estradiol in human serum or plasma.