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EIAgen SSB (detection of autoantibodies against SSB/La)



brief description

The detection of Anti-Nuclear Antibodies (ANA's) has long been an important tool in the diagnosis of systemic rheumatic diseases. The antigens used in their detection are purified by the saline extraction of human or animal nuclei, this has led to them being termed Extractable Nuclear Antigens (ENA's). The intracellular antigen SSB/La is a target for autoimmune response for many patients with Sistemic Lupus Erythematosus (SLE), Sjogren Syndrome (SS) and other connective tissue disease. Studies have shown that anti-SSB/La antibodies occur in 45-60% of patients with primary Sjogren Syndrome and approximately15% of patients with SLE, with a higher, approximately 70%, occurence in the SLE sicca syndrome . The autoantibodies are also often found in the presence of anti-SSA/Ro. The SSB/La antigen has been shown to be a highly phosphorylated ribonucleoprotein particle which under western Blot produces a band at 47KD. Autoantibodies to ENA's vary depending on disease state.

intended use

The EIAgen SSB is an Enzyme-linked immunosorbent assay method for the quantitative determination of specific IgG autoantibodies to SSB/La in human serum. The results of the anti-SSB assay can be used as an aid in the diagnosis of auto-immune diseases including Sjogren Syndrome (SS).

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