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EIAgen Scl70

brief description

The detection of Anti-Nuclear Antibodies (ANA's) has long been an important tool in the diagnosis of systemic rheumatic diseases. The antigens used in their detection are purified by the saline extraction of human or animal nuclei, this has led to them being termed Extractable Nuclear Antigens (ENA's). The intracellular antigen SCL-70 is a target for immune response with many patients with Primary Systemic Sclerosis (PSS or Scleroderma) and is considered to be specific for this condition. Anti-Scl-70 antibodies are found in approximately 70% of scleroderma patients, and, of these, around 20-30% have some sort of CREST syndrome. The Scl-70 antigen has been identified as being DNA topoisomerase I enzyme. Autoantibodies to ENA's vary depending on disease state.

intended use

The EIAgen Scl-70 is an Enzyme-linked immunosorbent assay method for the quantitative determination of specific IgG autoantibodies to Scl-70 in human serum. The results of the anti-Scl-70 assay can be used as an aid in the diagnosis of auto-immune diseases including Systemic Sclerosis.

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