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EIAgen Mitochondrial

brief description

Primary Biliary Cirrhosis (PBC) is a multisystemic disease with is usually detected by abnormal liver function. Over 95% of patients with PBC have circulating anti-Mitochondrial antibodies (AMA). Detection of AMA's are, therefore, an extremely valuable diagnostics test; absence of AMA virtually excludes the diagnosis of PBC. Not all patients with proven PBC are symptomatic and anti-Mitochondrial antibodies can be positive during the asymptomatic phase, which can last up to 20 years. AMA can also be found in a minority of patients with chronic active hepatitis or cirrhosis of unknown aetiology. AMA are also found, with very much lower frequency and at low levels antibodies, in other diseases and in apparently healthy individuals.

intended use

The EIAgen Mitochondrial is an Enzyme-linked immunosorbent assay method for the quantitative determination of specific IgG autoantibodies to Mitochondrial (M2) in human serum. The results of the anti-Mitochondrial (M2) assay can be used as an aid in the diagnosis of auto-immune diseases including Primary Biliary Cirrhosis (PBC).

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