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brief description

Autoantibodies recognising antigens in the cytoplasmic granules of neutrophils (ANCA) were first described in a population suffering from Wegener's granulomatosis. Initial investigations were carried out using immunofluorescence and two major patterns were observed. Peri-nuclear fluorescence (P-ANCA) was shown to be due to a number of antigens but primarily to the enzyme Myeloperoxidase (MPO), a 140 kD dimer which makes up almost 5% of the cell protein. In some sera, anti-myeloperoxidase antibodies give a more granular rather than peri-nuclear localisation. This is often due to their association to other ANCA's. Other antigens recognised by ANCA's and producing a P-ANCA pattern are Elastase, Cathepsin G and Lactoferrin. P-ANCA antibodies are found in most (90%) patients with microscopic polyarteritis nodosum).

intended use

The EIAgen P-ANCA (MPO) is an Enzyme-linked immunosorbent assay method for the quantitative determination of specific IgG autoantibodies to Myeloperoxidase (MPO) in human serum. The results of the anti-MPO assay can be used as an aid in the diagnosis of auto-immune diseases including Churg Strauss syndrome, Wegener's granulomatosis and microscopic polyarteritis.

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