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brief description

Autoantibodies recognising antigens in the cytoplasmic granules of neutrophils (ANCA) were first described in a population suffering from Wegener's granulomatosis. Initial investigations were carried out using immunofluorescence and two major patterns were observed: C- ANCA (cytoplasmic) and P-ANCA (peri-nuclear). C-ANCA has been shown to be mainly due to a 28kD serine proteinase termed proteinase-3 and it is found in the majority of patients with Wegener's granulomatosis. PR-3 is clinically significant as a diagnostic marker for Wegener's granulomatosis, a disease characterized by a necrotising vasculitis of the upper and lower respiratory tract and concomitant glomerulonephritis.

intended use

The EIAgen C-ANCA (PR-3) is an Enzyme-linked immunosorbent assay method for the quantitative determination of specific IgG autoantibodies to Proteinase-3 in human serum.

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